Hormone Therapy and Multiple Sclerosis

Biodentical Hormone Replacement Therapy in Denver

Hormone Therapy and Multiple Sclerosis

Biote hormone therapy may help people with MS

Hormone therapy and Multiple Sclerosis are closely linked. Biote therapy not only balances testosterone and estrogen levels, in fact, it helps thyroid function also.  The communication between brain neurohormones and hormone production is very important for good health and optimum function. Hormones influence multiple metabolic functions as well as mood, sleep, memory, neurogenesis, and neuronal myelination. However, demyelination being one of the most common signs of multiple sclerosis (MS), and remyelination is a major treatment target. Several hormones have been looked at as potential treatment for people living with MS.

Thyroid Hormones

The thyroid produces two hormones, T3 and T4. Thyroid hormones promote neuronal growth and synaptogenesis. These hormones are very important for the development of the cells responsible for myelination or “insulation” around the nerves. In particular T3, the active form of thyroid hormone, has been shown to increase remyelination and improve neurological symptoms in animal models of MS. Studies of people with MS have shown that treatment with a T3 synthetic analog is a safe treatment.  Researchers suggest that larger studies be done to determine it’s benefits.

T3 also supports nerve growth, proliferation, function, and myelination by producing nerve growth factors.

Our Biote Specialists Will Make Sure Your Thyroid Levels are Properly Balanced

Estrogen

Estrogens are a family of hormones that includes estrone, estradiol, and estriol. Estrogen supports nerve growth and the repair of damaged brain cells.(7) Estriol is thought to be the most beneficial estrogen with regard to MS. In a study of pregnant women with MS, the women showed a 70% drop in relapse rates in their third part of pregnancy when estriol levels are at their highest.(8) More so, in a 2-year study, women with relapsing-remitting MS were given standard of care medication plus oral estriol or placebo. Women supplementing their estriol had fewer relapses.(9)  Take a short quiz to find out if your hormones are in balance.

In a similar study however, oral estriol reduced the inflammatory immune response and caused brain lesions to shrink. The type of estrogen treatment is crucial. Natural or bioidentical hormones appear to have a greater positive effect; oral contraceptives with synthetic estrogens were shown not to have a beneficial impact on symptoms or relapse rates for MS. Hormone therapy and multiple sclerosis work well together.

Testosterone

Testosterone supports brain function and nerve differentiation. Low levels of testosterone in men with MS are lined with many health issues. A year long study of testosterone gel in men with MS found it improved their performance in mental tests and slowed brain atrophy. Studies also show that testosterone fights inflammation and protects nerves. Testosterone therapy may be most useful in men who have low levels of this hormone.  Take a short quiz to find out if your Testosterone levels are low.

BioTE Therapy Naturally Optimizes Your Bodies Hormone Function

Corticosteroids

Acute MS symptom flares can be treated with intravenous (IV) methylprednisolone. This drug decreases the number of T cells and proinflammatory cytokines like IFN-γ and TNF-α. Flares are managed with 1000mg methylprednisolone daily for 3-5 days.  The benefits of this type of therapy can last for up to 30 days. However, because of its impact on the HPA axis, side effects can includetroble sleeping, poor memory, and mood changes. Adrenocorticotropic hormone (ACTH), which stimulates endogenous cortisol release in the body, was shown to lower relapse rates more than methylprednisolone.

People with MS tend to have low levels of cortisol, and so doctors might consider supplementing their MS patients with 5 mg-10 mg/day of bioidentical hydrocortisone. At this dosage, there is no lowering of the HPA axis. On the contrary, it helps the body maintain optimal cortisol levels, which in turn relieve symptoms of fatigue, and promote healthy immune function.

Hormone Therapy and Multiple Sclerosis is a Well Studied Field

Melatonin

Melatonin is a neurohormone released by the pineal gland in accordance with the circadian rhythm. It has been studied greatly in people with sleep issues and is thought to be very safe. Recent evidence shows that melatonin production is poorly controlled in people with MS. In addition, people that work in the evening often have issues with melatonin production. This which may cause a greater risk of experiencing MS. Melatonin has been shown to improve MS symptoms in animal models. Findings from a study of people with MS suggest that supplementing with melatonin at 5mg per day for 90 days lowered  stress on the cells in the body and increased the quality of sleep.  Hormone therapy and Multiple Sclerosis are closely linked. Biote therapy can improve your life and your health!

References

This article originally appeared in restorativemedicine.org