Hormone Therapy and Multiple Sclerosis

Biodentical Hormone Replacement Therapy in Denver

Hormone Therapy and Multiple Sclerosis

Biote hormone therapy may help people with MS

Hormone therapy and Multiple Sclerosis are closely linked. BioTE hormone optimization affects not only testosterone and estrogen but also thyroid function.  The communication between brain neurohormone and endocrine hormone production is central to neuroendocrine integration. Neuroendocrine hormones influence multiple metabolic functions as well as mood, sleep, memory, neurogenesis, and neuronal myelination. Demyelination is one of the hallmarks of multiple sclerosis (MS), and remyelination is a major treatment target. Several hormones have been investigated as potential therapies for people living with MS.

Thyroid Hormones

The thyroid produces two hormones, T3 and T4. Thyroid hormones promote neuronal growth and synaptogenesis. They are also critical for the maturation of oligodendrocytes, the cells responsible for myelination.(1,2) In particular T3, the active form of thyroid hormone, has been shown to increase remyelination and improve neurological symptoms in animal models of MS.(3,4) Studies of people with MS have shown that treatment with a T3 synthetic analog is safe and well tolerated  Researchers recommended that larger clinical studies be done to determine its effectiveness.(5)

T3 also supports nerve growth, proliferation, function, and myelination by promoting nerve growth factor.(6)


Estrogens are a family of hormones that includes estrone, estradiol, and estriol. Estrogen supports nerve growth and the repair of damaged brain cells.(7) Estriol is thought to be the most beneficial estrogen with regard to MS. In a study of pregnant women with MS, participants had a 70% decrease in relapse rates in their third trimester of pregnancy.  This is when estriol levels are at their highest.(8) In a 2-year study, women with relapsing-remitting MS were given standard of care medication plus oral estriol or placebo. The women on oral estriol had significant reductions in relapse rates compared to the placebo group.(9)  Take a short quiz to find out if your hormones are in balance.

In a similar study, oral estriol decreased the inflammatory immune response and caused the regression of brain lesions.(10) The type of estrogen treatment is crucial. Natural or bioidentical hormones appear to have a greater beneficial effect; oral contraceptives with synthetic estrogens were shown not to have a beneficial impact on symptoms or relapse rates for MS.(11)


Testosterone supports cognition and nerve differentiation. Low levels of testosterone in men with MS are associated with disability.(12) A one-year pilot study of testosterone gel in men with MS found it improved cognitive performance and slowed brain atrophy.(13) Another small study demonstrated that testosterone was anti-inflammatory and neuroprotective.(14) Testosterone therapy may be most clinically useful in men who have low levels of this hormone.  Take a short quiz to find out if your Testosterone levels are low.

BioTE Therapy Naturally Supplements Your Bodies Own Hormone Levels.


Acute MS symptom flares can be treated with intravenous (IV) methylprednisolone. This drug decreases the concentration of T cells and proinflammatory cytokines like IFN-γ and TNF-α.(15) Flares are managed with 1000mg methylprednisolone daily for 3-5 days.  The results of this type of therapy can last up to 30 days. However, because of its impact on the HPA axis, side effects can include insomnia, poor memory, and mood changes.(16) Adrenocorticotropic hormone (ACTH), which stimulates endogenous cortisol release in the body, was shown to decrease relapse rates more than methylprednisolone.(17) People with MS tend to have low levels of cortisol, and so clinicians might consider supplementing their MS patients with 5 mg-10 mg/day of bioidentical hydrocortisone. At this physiological dosage range, there is no suppression of the HPA axis. On the contrary, it helps the body maintain optimal cortisol levels, which in turn relieve symptoms of fatigue, and promote healthy immune function.


Melatonin is a neurohormone released by the pineal gland in accordance with the circadian rhythm. It has been studied extensively in sleep disorders and is generally regarded as safe.(18) Recent evidence indicates that melatonin secretion is poorly regulated in people with MS.(19) In addition, night-shift workers often have disrupted melatonin secretion, which may be associated with an increased risk for developing MS.(20) Melatonin has been shown to improve MS symptoms in animal models.(21) Findings from a study of people with MS suggest that supplementation with melatonin at 5mg per day for 90 days improved oxidative stress parameters and quality of sleep.(21)  Hormone therapy and Multiple Sclerosis are closely linked. BioTE bio-identical hormone therapy is a safe proven way to improve your health and your life.


  1. https://pubmed.ncbi.nlm.nih.gov/9097076/
  2. https://link.springer.com/article/10.1007/s12035-015-9375-z
  3. https://pubmed.ncbi.nlm.nih.gov/21707794/
  4. https://pubmed.ncbi.nlm.nih.gov/32120028/
  5. https://www.sciencedirect.com/science/article/abs/pii/0165380696001058
  6. https://pubmed.ncbi.nlm.nih.gov/25417212/
  7. https://pubmed.ncbi.nlm.nih.gov/9682040/
  8. https://pubmed.ncbi.nlm.nih.gov/26621682/
  9. https://pubmed.ncbi.nlm.nih.gov/12325070/
  10. https://pubmed.ncbi.nlm.nih.gov/28093732/
  11. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188801/
  12. https://pubmed.ncbi.nlm.nih.gov/17502467/
  13. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518142/
  14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1906276/
  15. https://pubmed.ncbi.nlm.nih.gov/17466428/
  16. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400152/
  17. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1490287/
  18. https://pubmed.ncbi.nlm.nih.gov/31845043/
  19. https://oem.bmj.com/content/76/10/733
  20. https://pubmed.ncbi.nlm.nih.gov/24974099/
  21. https://pubmed.ncbi.nlm.nih.gov/24974099/

This article originally appeared at: https://restorativemedicine.org/digest/hormone-therapy-multiple-sclerosis/